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1 Measurements of the binding of 12‐alpha‐[3H]‐digoxin to the membranes of intact erythrocytes, erythrocyte 86rubidium uptake and intraerythrocytic sodium concentrations have been made in the red cells of various groups of patients‐those who have not received digoxin, those during the early phases of treatment, those during chronic (greater than 2 months) treatment, and those toxic. 2 The values of those measurements in the patients in the early phases of therapy and in the toxic patients differed significantly from those of the untreated patients. 3 However, the values in the chronically treated patients were not different from those of the untreated patients. 4 The results suggest that the biochemical pharmacological effects of digoxin which occur during the early phases of therapy do not persist in the long‐term. 5 The possible clinical significance of these observations is discussed. 1979 The British Pharmacological Society

Original publication




Journal article


British Journal of Clinical Pharmacology

Publication Date





135 - 142