What, if the a pandemic arrives? Speaking about pre-pandemic vaccines
A very important seminar sponsored by WHO and FDA took place in Bethesda in 2007. The evaluation of the link between surrogate end points and effective ones in the production of pre pandemic vaccines was the topic. If the in vitro titre of anti HI corresponds to a real protection or which is the quantitative threshold of efficacy were questions without sure answers. Same problems for H5N1. So maybe "More is better" isn't enough.