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The undertaking of large-scale DNA sequencing screens for somatic variants in human cancers requires accurate and rapid processing of traces for variants. Due to their often aneuploid nature and admixed normal tissue, heterozygous variants found in primary cancers are often subtle and difficult to detect. To address these issues, we have developed a mutation detection algorithm, AutoCSA, specifically optimized for the high throughput screening of cancer samples. © 2007 The Author(s).

Original publication

DOI

10.1093/bioinformatics/btm152

Type

Conference paper

Publication Date

01/07/2007

Volume

23

Pages

1689 - 1691