Research groups
Ly-Mee Yu
M.Sc., DPhil
Professor of Clinical Trials and Biostatistics
- Co-Director of Primary Care Clinical Trials Unit
- Co-Director of the NIHR Research Support Service (RSS) Hub and Specialist Centre for Public Health (hosted by Southampton)
I joined the Department in 2013 after previously working at the Centre for Statistics in Medicine where I led a team of statisticians, collaborating on a variety of clinical studies (predominately randomised controlled trials) and supported numerous funding applications (e.g. NIHR, FP7, MRC, and Wellcome Trust). I have over 30 years of experience as a medical statistician and specifically in clinical trials for the past 20 years. I have worked in a wide range of clinical areas, including but not limited to, renal disease, behavioural medicine, vaccinology, cardiovascular medicine, infectious disease, surgery, allied health, mental health, neurosciences, respiratory, and orthopaedics. I have published over 200 articles in peer-reviewed journals such as the Lancet, JAMA and the BMJ. I am currently the lead statistician of two platform adaptive decentralised clinical trials to evaluate treatment for COVID-19 in the community.
I am currently a Co-Director the Primary Care Clinical Trials Unit (CTU), and Co-Director of the NIHR Research Support Services (hosted by Southampton). I am a panel member of the NIHR Research Programme for Social Care and the Definitive Interventions and Feasibility Awards (HRB Ireland). I am also a member of the CHM Cancer Vaccines Expert Working Group (CVEWG). I have sat on various NIHR funding boards and the Oxford Tropical Research Ethnics Committee. I am also a chair/member of data and safety monitoring committee, and the trial steering committee of several national and international trials.
My research interests include trial methodology, such as platform trials, decentralised clinical trials, missing data, covariate adjustment in clinical trials.
Recent publications
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Real-world waitlist randomised controlled trial of gameChange VR to treat severe agoraphobic avoidance in patients with psychosis: A study protocol
Journal article
Freeman D. et al, (2025), BMJ Open, 15
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Removal notice to “Ivermectin and COVID-19” Journal of Infection 91 (2025) 106530 (Journal of Infection (2025) 91(2), (S0163445325001240), (10.1016/j.jinf.2025.106530))
Journal article
Butler CC. et al, (2025), Journal of Infection, 91
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The PRINCIPLE randomised controlled open label platform trial of hydroxychloroquine for treating COVID19 in community based patients at high risk
Journal article
Hobbs FDR. et al, (2025), Scientific Reports, 15
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Ivermectin and COVID-19.
Journal article
Butler CC. et al, (2025), J Infect
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A viro-immunological model to characterize the antiviral effect of molnupiravir in SARS-CoV-2-infected outpatients: implication for treatment duration.
Journal article
Nguyen BT. et al, (2025), J Infect Dis
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The impact of the COVID-19 pandemic on antimicrobial usage: an international patient-level cohort study.
Journal article
Farzana R. et al, (2025), JAC Antimicrob Resist, 7
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Benefits of aldosterone receptor antagonism in chronic kidney disease: the BARACK-D RCT.
Journal article
Hobbs FDR. et al, (2025), Health Technol Assess, 29, 1 - 130
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Pramipexole augmentation for the acute phase of treatment-resistant, unipolar depression: a placebo-controlled, double-blind, randomised trial in the UK
Journal article
Browning M. et al, (2025), Lancet Psychiatry
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Self-monitoring of blood pressure following a stroke or transient ischaemic attack (TASMIN5S): a randomised controlled trial
Journal article
McManus RJ. et al, (2024), BMC Cardiovascular Disorders, 24
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Supporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D pilot): results of a feasibility randomised trial
Journal article
Farmer AJ. et al, (2024), Pilot and Feasibility Studies, 10
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User engagement in clinical trials of digital mental health interventions: a systematic review
Journal article
Elkes J. et al, (2024), BMC Medical Research Methodology, 24
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Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage
Journal article
Toader AM. et al, (2024), Trials, 25
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Utilising primary care electronic health records to deliver the ALABAMA randomised controlled trial of penicillin allergy assessment
Journal article
Ahmed S. et al, (2024), Trials, 25
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Favipiravir for COVID-19 in adults in the community in PRINCIPLE, an open-label, randomised, controlled, adaptive platform trial of short- and longer-term outcomes
Journal article
Hobbs FR. et al, (2024), Journal of Infection, 89
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Effect of antihypertensive deprescribing on hospitalisation and mortality: long-term follow-up of the OPTiMISE randomised controlled trial
Journal article
Sheppard JP. et al, (2024), The Lancet Healthy Longevity, 5, e563 - e573
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Nurse-delivered sleep restriction therapy to improve insomnia disorder in primary care: the HABIT RCT
Journal article
Kyle SD. et al, (2024), Health Technology Assessment, 1 - 107
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FOUND Trial: randomised controlled trial study protocol for case finding of obstructive sleep apnoea in primary care using a novel device
Journal article
Miller MA. et al, (2024), BMJ Open, 14
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Effect of antihypertensive deprescribing on serious adverse events, mortality, and cardiovascular disease: Long-term follow-up of the OPTiMISE randomised controlled trial
Journal article
SHEPPARD J. et al, (2024), The Lancet Healthy Longevity
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Paediatric meningitis in the conjugate vaccine era and a novel clinical decision model to predict bacterial aetiology
Journal article
Martin NG. et al, (2024), Journal of Infection, 88
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Intravenous immunoglobulin treatment for encephalitis in children aged 6 months to 16 years: the IgNiTE RCT
Journal article
Iro MA. et al, (2024), Efficacy and Mechanism Evaluation, 1 - 53

