Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
Van Haaften G., Dalgliesh GL., Davies H., Chen L., Bignell G., Greenman C., Edkins S., Hardy C., O'Meara S., Teague J., Butler A., Hinton J., Latimer C., Andrews J., Barthorpe S., Beare D., Buck G., Campbell PJ., Cole J., Forbes S., Jia M., Jones D., Kok CY., Leroy C., Lin ML., McBride DJ., Maddison M., Maquire S., McLay K., Menzies A., Mironenko T., Mulderrig L., Mudie L., Pleasance E., Shepherd R., Smith R., Stebbings L., Stephens P., Tang G., Tarpey PS., Turner R., Turrell K., Varian J., West S., Widaa S., Wray P., Collins VP., Ichimura K., Law S., Wong J., Yuen ST., Leung SY., Tonon G., Depinho RA., Tai YT., Anderson KC., Kahnoski RJ., Massie A., Khoo SK., Teh BT., Stratton MR., Futreal PA.
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene. © 2009 Nature America, Inc. All rights reserved.