A gene map of the human genome
Schuler GD., Boguski MS., Stewart EA., Aggarwal A., Bajorek E., Chu A., Cowles S., Fan JB., Fang N., Hadley D., Harris M., Brady S., Hussain S., Mader C., Maratukulam A., McKusick KB., Perkins S., Piercy M., Qin F., Quackenbush J., Reif T., Sanders C., She X., Sun WL., Tabar P., Vollrath D., Voyticky S., Myers RM., Cox DR., Stein LD., Birren BB., Castle AB., Hui L., Ma J., Nusbaum HC., Page DC., Rozen S., Silva J., Slonim DK., Wu X., Gyapay G., Bentolila S., Chiannilkulchai N., Drouot N., Duprat S., Fizames C., Muselet D., Vega-Czarny N., Beckmann JS., Weissenbach J., Rice K., Butler A., Clee C., Dibling T., Dunham I., East C., Edwards C., Garrett C., Green L., Harrison P., Hicks A., Holloway E., MacGilvery A., Mungall A., Peck A., Ranby S., Soderlund C., Wilmer T., Bentley D., Deloukas P., White RE., Day PJR., Louis-Dit-Sully C., Thangarajah T., James MR., Rodriguez-Tomé P., Matise TC., Morissette J., Adams MD., Brandon R., Phillips C., Sandusky M., Venter JC., Auffray C., Houlgatte R., Walter NAR., lorio KR., Berry R., Sikela JM., Dehejia A., Ide SE., Polymeropoulos MH., Torres R., Goodfellow PN., Schmitt K., Hudson JR., Lee WY., Swanson K., Seki N., Nagase T.
The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeast artificial chromosome library. More than 16,000 human genes have been mapped relative to a framework map that contains about 1000 polymorphic genetic markers. The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease. The integrated resource is available through a site on the World Wide Web at http://www.ncbi.nlm.nih.gov/SCIENCE96/.